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Chapter 15. Atomic Force Microscopy in the Study of Macromolecular Interactions in Hemostasis and Thrombosis: Utility for Investigation of the Antiphospholipid Syndrome

  1. Bhanu P. Jena PhD5,
  2. J. K. Heinrich Hörber PhD6
  1. William J. Montigny1,
  2. Anthony S. Quinn2,
  3. Xiao-Xuan Wu3,
  4. Edwin G. Bovill4,
  5. Jacob H. Rand3,
  6. Douglas J. Taatjes2

Published Online: 4 NOV 2005

DOI: 10.1002/0470007702.ch15

Book Title

Force Microscopy: Applications in Biology and Medicine

Force Microscopy: Applications in Biology and Medicine

Additional Information

How to Cite

Montigny, W. J., Quinn, A. S., Wu, X.-X., Bovill, E. G., Rand, J. H. and Taatjes, D. J. (2005) Atomic Force Microscopy in the Study of Macromolecular Interactions in Hemostasis and Thrombosis: Utility for Investigation of the Antiphospholipid Syndrome, in Force Microscopy: Applications in Biology and Medicine (eds B. P. Jena and J. K. H. Hörber), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/0470007702.ch15

Editor Information

  1. 5

    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA

  2. 6

    Department of Physics, University of Bristol, Bristol, United Kingdom

Author Information

  1. 1

    Microscopy Imaging Center, College of Medicine, University of Vermont, Bulington, Vermont, USA

  2. 2

    Department of Pathology and Microscopy Imaging Center, College of Medicine, University of Vermont, Burlington, Vermont, USA

  3. 3

    Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA

  4. 4

    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont, USA

Publication History

  1. Published Online: 4 NOV 2005
  2. Published Print: 21 JUN 2006

ISBN Information

Print ISBN: 9780471396284

Online ISBN: 9780470007709

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CHAPTER TOOLS

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Keywords:

  • macromolecular interactions in hemostasis and thrombosis;
  • AFM and lipids;
  • antiphospholipid syndrome and AFM study

Summary

This chapter contains sections titled:

  • Introduction

  • Atomic Force Microscopy

  • AFM and Lipids

  • AFM and Haemostatic Proteins

  • The Antiphospholipid Syndrome (APS)

  • Mechanism for the Anticoagulant Effects of aPL Antibodies

  • β2GPI Cofactor

  • Annexin A5

  • Disruption of the AnxA5 Anticoagulant Shield

  • Contributions of AFM to the Study of the Antiphospholipid Syndrome

  • Summary

  • Acknowledgment

  • References

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