Chapter 9. Lactate, Glycogen and Fatigue

  1. Robert G. Shulman1 and
  2. Douglas L. Rothman2
  1. Robert G. Shulman1 and
  2. Douglas L. Rothman2

Published Online: 19 AUG 2005

DOI: 10.1002/0470011505.ch9

Metabolomics by In Vivo NMR

Metabolomics by In Vivo NMR

How to Cite

Shulman, R. G. and Rothman, D. L. (2004) Lactate, Glycogen and Fatigue, in Metabolomics by In Vivo NMR (eds R. G. Shulman and D. L. Rothman), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470011505.ch9

Editor Information

  1. 1

    Yale University School of Medicine, Department of Diagnostic Radiology, PO Box 208024, New Haven, CT 06520-8024, USA

  2. 2

    Department of Diagnostic Radiology, Yale University School of Medicine, MR Center, PO Box 208043, New Haven, CT 06520-8043, USA

Author Information

  1. 1

    Yale University School of Medicine, Department of Diagnostic Radiology, PO Box 208024, New Haven, CT 06520-8024, USA

  2. 2

    Department of Diagnostic Radiology, Yale University School of Medicine, MR Center, PO Box 208043, New Haven, CT 06520-8043, USA

Publication History

  1. Published Online: 19 AUG 2005
  2. Published Print: 17 DEC 2004

ISBN Information

Print ISBN: 9780470847190

Online ISBN: 9780470011508

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Keywords:

  • lactate efflux;
  • monocarboxylic acid transporters (MCT);
  • glycogenolysis;
  • fatigue and glycogen consumption;
  • glycogen shunt;
  • contraction-intercontraction cycle;
  • anaerobic glycolysis;
  • rapid non-oxidative ATP production

Summary

This chapter contains sections titled:

  • Model for Non-oxidative Production of Lactate under Conditions in Exercising Muscle

  • Evidence for Rapid Energy Consumption in Muscle

  • The Interplay between Glycogen, PCr and Lactate Oxidation to Produce ATP during and After a Muscle Contraction

  • Evidence for Glycogen's Role in Generating ATP during Contraction

  • Biochemical Evidence for the Model

  • Evidence from 13C NMR of Human Muscle for Glycogen Turnover during Exercise

  • Lactate Efflux in Brain

  • Proposed Role for Glycogen During Fatigue

  • Summary of the Glycogen Shunt and Lactate Generation