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Homeobox gene repertoires: implications for the evolution of diversity

Part 1. Genetics

1.1. Genetic Variation and Evolution

Specialist Review

  1. Claudia Kappen

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g101209

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Kappen, C. 2005. Homeobox gene repertoires: implications for the evolution of diversity. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.1:3.

Author Information

  1. University of Nebraska Medical Center, Omaha, NE, USA

Publication History

  1. Published Online: 15 JAN 2005

Abstract

Homeobox genes are key regulators of morphogenetic processes in developing organisms, and are involved in the formation and differentiation of multiple tissues and cell types. The strong conservation of homeobox gene sequences indicates that many species share a common repertoire of homeobox genes. Experimental evidence provides support for conserved as well as divergent functions, raising the question how homeobox genes evolved in distinct species and in which way they contributed to the evolution of different morphologies. This article examines the composition of homeobox gene repertoires in diverse animals at the whole-genome level, with the aim to understand the underlying mechanisms of evolution in this multigene family.

Keywords:

  • duplication;
  • gene repertoire;
  • phylogenetic;
  • cladistic;
  • clade;
  • cluster;
  • complexity;
  • molecular evolution;
  • homeobox;
  • homeodomain;
  • Hox;
  • multigene family