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Genetic signatures of natural selection

Part 1. Genetics

1.1. Genetic Variation and Evolution

Short Specialist Review

  1. Molly Przeworski1,
  2. Carlos D. Bustamante2

Published Online: 15 OCT 2004

DOI: 10.1002/047001153X.g101312

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Przeworski, M. and Bustamante, C. D. 2004. Genetic signatures of natural selection. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.1:7.

Author Information

  1. 1

    Brown University, Providence, RI, USA

  2. 2

    Cornell University, Ithaca, NY, USA

Publication History

  1. Published Online: 15 OCT 2004

Abstract

Molecular population genetic data carry information about the evolutionary forces that have shaped the history of the species and, in particular, about past adaptations. Here, we review how nucleotide sequence variation within and between species can be used to detect and characterize natural selection. We provide a brief description of tests of neutrality for various types of data, detail the limitations of current methods, and summarize recent theoretical advances that may be important in moving this growing field forward.

Keywords:

  • natural selection;
  • polymorphism;
  • divergence;
  • tests of neutrality;
  • demography