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Measuring variation in natural populations: a primer

Part 1. Genetics

1.1. Genetic Variation and Evolution

Basic Techniques and Approaches

  1. Henry Harpending

Published Online: 15 JUL 2005

DOI: 10.1002/047001153X.g101403

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Harpending, H. 2005. Measuring variation in natural populations: a primer. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.1:10.

Author Information

  1. University of Utah, Salt Lake City, UT, USA

Publication History

  1. Published Online: 15 JUL 2005

Abstract

In this brief primer, I will first discuss common kinds of data sources appropriate for measuring variation and then describe statistical computations appropriate to each. With one exception all the methods I discuss are equivalent in the sense that they estimate average coalescence times of pairs of marker loci chosen from a population.

Keywords:

  • genetic diversity;
  • variation;
  • Fst;
  • mean pairwise difference;
  • short tandem repeats;
  • segregating sites