Acquired chromosome abnormalities: the cytogenetics of cancer
Part 1. Genetics
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Gollin, S. M. 2005. Acquired chromosome abnormalities: the cytogenetics of cancer. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.2:14.
- Published Online: 15 APR 2005
Cancer is a disease in which genetic alterations, most frequently chromosomal rearrangements, are acquired in somatic cells resulting in loss of critical cellular checks and balances. This leads to cellular dysregulation, proliferation, and ultimately, malignant transformation. Cancer cytogenetics is the subdiscipline of genetics in which the chromosomal abnormalities present in cancers are identified and investigated. This includes correlation of the cytogenetic abnormalities with clinical diagnosis, prognosis and response to therapy, and may extend to identification of the genes disrupted and/or dysregulated as a result of the chromosomal aberrations. The history of cancer cytogenetics, a description the cytogenetic methodology that has developed and evolved over the past half-century, clinical applications of cancer cytogenetics, and mechanisms by which cytogenetic abnormalities arise in cancer cells are described in this contribution to the literature.