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Acquired chromosome abnormalities: the cytogenetics of cancer

Part 1. Genetics

1.2. Cytogenetics

Specialist Review

  1. Susanne M. Gollin

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g102204

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Gollin, S. M. 2005. Acquired chromosome abnormalities: the cytogenetics of cancer. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.2:14.

Author Information

  1. University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

Cancer is a disease in which genetic alterations, most frequently chromosomal rearrangements, are acquired in somatic cells resulting in loss of critical cellular checks and balances. This leads to cellular dysregulation, proliferation, and ultimately, malignant transformation. Cancer cytogenetics is the subdiscipline of genetics in which the chromosomal abnormalities present in cancers are identified and investigated. This includes correlation of the cytogenetic abnormalities with clinical diagnosis, prognosis and response to therapy, and may extend to identification of the genes disrupted and/or dysregulated as a result of the chromosomal aberrations. The history of cancer cytogenetics, a description the cytogenetic methodology that has developed and evolved over the past half-century, clinical applications of cancer cytogenetics, and mechanisms by which cytogenetic abnormalities arise in cancer cells are described in this contribution to the literature.

Keywords:

  • translocations;
  • leukemia;
  • neoplasms;
  • genetics