Standard Article

Preimplantation genetic diagnosis for chromosome abnormalities

Part 1. Genetics

1.2. Cytogenetics

Short Specialist Review

  1. Santiago Munné

Published Online: 15 JUL 2005

DOI: 10.1002/047001153X.g102310

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Munné, S. 2005. Preimplantation genetic diagnosis for chromosome abnormalities. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.

Author Information

  1. Yale University, New Haven, CT, USA

Publication History

  1. Published Online: 15 JUL 2005

Abstract

Preimplantation genetic diagnosis (PGD) is the earliest form of prenatal diagnosis and has been used in over 5000 infertile patient procedures to improve pregnancy outcome for in vitro fertilization (IVF). PGD has also been used to limit spontaneous abortions and chromosomally unbalanced or aneuploid offspring in patients of advanced maternal age or carriers of translocations or other chromosome abnormalities.

Keywords:

  • recurrent miscarriages;
  • recurrent pregnancy loss;
  • translocations;
  • aneuploidy;
  • down syndrome;
  • inversions