Developmental regulation of DNA methyltransferases
Part 1. Genetics
Published Online: 15 APR 2006
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Lees-Murdock, D. J. and Walsh, C. P. 2006. Developmental regulation of DNA methyltransferases. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.3.
- Published Online: 15 APR 2006
The mammalian genome appears to undergo two waves of demethylation, one in the preimplantation embryo and the other in the germ cells of the primitive gonad. Methylation is reestablished at the egg cylinder stage and either in the prospermatogonia for the male or the growing oocyte for the female. Precise control of methyltransferase activity is required to ensure that these events occur reliably. Here we discuss the various mechanisms, from promoter switching to protein stabilization, used to regulate the maintenance and de novo enzymes catalyzing CpG methylation during development, and how these converge to limit the periods during which all the required factors are present in the nucleus.
- subcellular localization