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Evolution of genomic imprinting in mammals

Part 1. Genetics

1.3. Epigenetics

Short Specialist Review

  1. Hamish G. Spencer

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g103312

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Spencer, H. G. 2005. Evolution of genomic imprinting in mammals. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.3:37.

Author Information

  1. University of Otago, Dunedin, New Zealand

Publication History

  1. Published Online: 15 NOV 2005

Abstract

Genomic imprinting is an evolutionary paradox because it seems at first glance to be disadvantageous: the monoallelic expression it entails means that recessive deleterious mutations cannot be masked. Several hypotheses seek to resolve the paradox, and the strengths and weaknesses of the most plausible of these – ovarian time bomb, genomic conflict, differential selection on males and females – are discussed.

Keywords:

  • genetic conflict;
  • ovarian time bomb;
  • prevention of parthenogenesis;
  • differential selection on males and females