Imprinting and behavior
Part 1. Genetics
Short Specialist Review
Published Online: 15 OCT 2004
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Curley, J. P. and Keverne, E. B. 2004. Imprinting and behavior. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.3:39.
- Published Online: 15 OCT 2004
There is accumulating evidence for the role of imprinted genes in the regulation of mammalian behavior. Many imprinted genes are expressed in the brain and are important for its development. In particular, it appears that paternally and maternally expressed genes are critical for the normal development of the hypothalamus/limbic system and cortex/striatum respectively. Furthermore, several imprinted genes have been identified as candidate genes for human behavioral disorders. More recent research has focused on the behavioral phenotypic effects in mice carrying targeted mutations of specific imprinted genes. Two of these, the paternally expressed Mest/Peg1 and Peg3 genes, have been shown to regulate maternal care.
- genomic imprinting;
- imprinted genes;
- maternal care