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Epigenetic reprogramming in germ cells and preimplantation embryos

Part 1. Genetics

1.3. Epigenetics

Short Specialist Review

  1. Abraham L. Kierszenbaum

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g103320

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Kierszenbaum, A. L. 2005. Epigenetic reprogramming in germ cells and preimplantation embryos. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.3:33.

Author Information

  1. The Sophie Davis School of Biomedical Education, and The City University of New York Medical School, New York, NY, USA

Publication History

  1. Published Online: 15 NOV 2005

Abstract

DNA methylation and histone modifications are major epigenetic modifications with a major impact on gametogenesis and early embryo development. A key objective during these events is to erase and reprogram the methylation patterns to enable the developmental potential of the gametes and embryogenesis. A disruption of epigenetic reprogramming can lead to the dysregulation of developmental processes and to various diseases. Understanding the chronology and mechanism of epigenetic reprogramming during gametogenesis and in early development can lead to advances in therapeutic cloning and clinical intervention through assisted reproductive technology.

Keywords:

  • spermatogenesis;
  • oogenesis;
  • fertilization;
  • blastocyst;
  • DNA methyltransferases;
  • histone modifications