Epigenetic reprogramming in germ cells and preimplantation embryos
Part 1. Genetics
Short Specialist Review
Published Online: 15 NOV 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Kierszenbaum, A. L. 2005. Epigenetic reprogramming in germ cells and preimplantation embryos. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.3:33.
- Published Online: 15 NOV 2005
DNA methylation and histone modifications are major epigenetic modifications with a major impact on gametogenesis and early embryo development. A key objective during these events is to erase and reprogram the methylation patterns to enable the developmental potential of the gametes and embryogenesis. A disruption of epigenetic reprogramming can lead to the dysregulation of developmental processes and to various diseases. Understanding the chronology and mechanism of epigenetic reprogramming during gametogenesis and in early development can lead to advances in therapeutic cloning and clinical intervention through assisted reproductive technology.
- DNA methyltransferases;
- histone modifications