Consequences of error
Part 1. Genetics
1.4. Gene Mapping
Published Online: 15 JUL 2006
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Gordon, D. and Finch, S. J. 2006. Consequences of error. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.4.
- Published Online: 15 JUL 2006
Although misclassification errors are among the most ubiquitous elements of any gene mapping study, their consequences are often omitted or ignored. These errors, however, can cause deleterious results for the analysis of genetic data. Here we review the consequences of misclassification error in genetic linkage and association analysis. We also present recent methodological advances to estimate error rates and to incorporate errors into statistical tests of gene mapping. Computations for many of these advances may be performed through freely available software.
- statistical genetics;
- genotyping error;
- diagnostic or diagnosis error;
- pedigree error;
- phenotype error;
- sample size;