Standard Article

Consequences of error

Part 1. Genetics

1.4. Gene Mapping

Specialist Review

  1. Derek Gordon1,
  2. Stephen J. Finch2

Published Online: 15 JUL 2006

DOI: 10.1002/047001153X.g104213

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Gordon, D. and Finch, S. J. 2006. Consequences of error. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.4.

Author Information

  1. 1

    Rutgers University, Piscataway, NY, US

  2. 2

    Stony Brook University, Stony Brook, NY, US

Publication History

  1. Published Online: 15 JUL 2006

Abstract

Although misclassification errors are among the most ubiquitous elements of any gene mapping study, their consequences are often omitted or ignored. These errors, however, can cause deleterious results for the analysis of genetic data. Here we review the consequences of misclassification error in genetic linkage and association analysis. We also present recent methodological advances to estimate error rates and to incorporate errors into statistical tests of gene mapping. Computations for many of these advances may be performed through freely available software.

Keywords:

  • statistical genetics;
  • misclassification;
  • genotyping error;
  • diagnostic or diagnosis error;
  • pedigree error;
  • phenotype error;
  • sample size;
  • linkage;
  • association