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Algorithmic improvements in gene mapping

Part 1. Genetics

1.4. Gene Mapping

Short Specialist Review

  1. Gonçalo R. Abecasis,
  2. Yu Zhao

Published Online: 15 JUL 2005

DOI: 10.1002/047001153X.g104301

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Abecasis, G. R. and Zhao, Y. 2005. Algorithmic improvements in gene mapping. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.4:52.

Author Information

  1. University of Michigan, Ann Arbor, MI, USA

Publication History

  1. Published Online: 15 JUL 2005

Abstract

The analysis of human gene mapping data presents daunting computational challenges. Improvements in laboratory technology have motivated the development and refinement of increasingly sophisticated algorithms for the analysis of human pedigrees. We review and summarize some of the more important developments, and present a short history of the software packages that are now in widespread use in human gene mapping studies.

Keywords:

  • gene-mapping algorithms;
  • computational methods;
  • human pedigrees;
  • Elston–Stewart;
  • Lander–Green;
  • stochastic methods