Computation of LOD scores
Part 1. Genetics
1.4. Gene Mapping
Basic Techniques and Approaches
Published Online: 15 JAN 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Hinrichs, A. L. and Suarez, B. K. 2005. Computation of LOD scores. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.4:56.
- Published Online: 15 JAN 2005
Linkage analysis has become the key tool for the identification of genetic factors causing human disorders. Methodology has been developed and continues to be developed to analyze linkage data for a variety of disease models and pedigree structures. We present detailed examples of three basic methods: parametric (for both dominant and recessive traits), affected sibling pair, and nonparametric linkage.
- LOD score;