Standard Article

Genetics of complex diseases: lessons from type 2 diabetes

Part 1. Genetics

1.5. Complex Traits and Diseases

Introductory Review

  1. Leif Groop,
  2. Peter Almgren

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g105108

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Groop, L. and Almgren, P. 2005. Genetics of complex diseases: lessons from type 2 diabetes. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.5:57.

Author Information

  1. Lund University, Malmö, Sweden

Publication History

  1. Published Online: 15 NOV 2005

Abstract

While the genetic causes of monogenic disorders have been successfully identified in the past, the success in dissecting the genetics of complex polygenic diseases has been limited. There are several reasons for these shortcomings. For many complex diseases, variants in several genes increase the susceptibility to the disease but the individual risk may be too low to be detected by current methods. In addition, the genetic variants almost always require environmental triggers, which need to be taken into account in the search for the underlying genetic causes. The rapid development of high-throughput tools for genotyping and improved understanding of basic concepts of complex diseases may open up for some future success.

Keywords:

  • genetics;
  • complex disease;
  • polygenic;
  • linkage study;
  • genome-wide scan;
  • association study;
  • single nucleotide polymorphism;
  • type 2 diabetes