Concept of complex trait genetics
Part 1. Genetics
1.5. Complex Traits and Diseases
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Weiss, K. M. and Buchanan, A. V. 2005. Concept of complex trait genetics. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.5:58.
- Published Online: 15 APR 2005
Complex traits are those for which there is no single main-effect cause with high predictive power. These traits generally involve multifactorial causation, including gene–gene and/or gene–environment interaction, although generally an exhaustive set of causal factors has not been possible to enumerate. Common complex chronic diseases in humans illustrate this heterogeneous category of traits and possible reasons for the difficulty human genetics and epidemiology have had in parsing them. It may be that a history of success with “simpler” diseases, those caused by strong environmental risk factors or single genes with strong effect, predisposes investigators to assume a similar model for complex disease. However, there are numerous reasons that complex diseases do not conform to the same model.
- complex traits;
- complex disease;
- common chronic disease;
- human genetics;