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Allergy and asthma

Part 1. Genetics

1.5. Complex Traits and Diseases

Short Specialist Review

  1. Miriam F. Moffatt,
  2. William O.C. Cookson

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g105303

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Moffatt, M. F. and Cookson, W. O. 2005. Allergy and asthma. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.5:61.

Author Information

  1. University of Oxford, Oxford, UK

Publication History

  1. Published Online: 15 APR 2005

Abstract

Asthma and eczema (atopic dermatitis, AD) are the most common chronic diseases of childhood. These diseases are characterized by the production of high levels of immunoglobulin E in response to common allergens. Their development depends on both genetic and environmental factors. Genes and genetic loci that are associated with increased susceptibility to asthma and AD have been described. A surprising number of these are expressed in the mucosa and epidermis, suggesting that events at epithelial surfaces may be driving disease processes.

Keywords:

  • asthma;
  • allergy;
  • genetics