Allergy and asthma
Part 1. Genetics
1.5. Complex Traits and Diseases
Short Specialist Review
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Moffatt, M. F. and Cookson, W. O. 2005. Allergy and asthma. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.
- Published Online: 15 APR 2005
Asthma and eczema (atopic dermatitis, AD) are the most common chronic diseases of childhood. These diseases are characterized by the production of high levels of immunoglobulin E in response to common allergens. Their development depends on both genetic and environmental factors. Genes and genetic loci that are associated with increased susceptibility to asthma and AD have been described. A surprising number of these are expressed in the mucosa and epidermis, suggesting that events at epithelial surfaces may be driving disease processes.