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Complexity of cancer as a genetic disease

Part 1. Genetics

1.5. Complex Traits and Diseases

Short Specialist Review

  1. Tea Vallenius,
  2. Tomi P. Mäkelä

Published Online: 15 JUL 2005

DOI: 10.1002/047001153X.g105313

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Vallenius, T. and Mäkelä, T. P. 2005. Complexity of cancer as a genetic disease. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.5:65.

Author Information

  1. University of Helsinki, Helsinki, Finland

Publication History

  1. Published Online: 15 JUL 2005

Abstract

Our understanding of cancer as a genetic disease is increasingly growing using information from genome-scale experimental approaches, and the focus is turning from analyzing single genes to analyzing signaling networks. Together with the first targeted therapy successes, this has resulted in an excitement and optimism in the field, while at the same time improved classification and diagnostics are identifying at increasing accuracy the patients who will benefit from a given therapy.

Keywords:

  • cancer;
  • genetic;
  • targeted therapy;
  • stroma;
  • mutation;
  • malignant