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Inflammation and inflammatory bowel disease

Part 1. Genetics

1.5. Complex Traits and Diseases

Short Specialist Review

  1. Christopher G. Mathew

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g105316

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Mathew, C. G. 2005. Inflammation and inflammatory bowel disease. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.5:62.

Author Information

  1. King's College London, London, UK

Publication History

  1. Published Online: 15 NOV 2005

Abstract

The identification of NOD2 (now called CARD15) as a susceptibility gene for Crohn's disease was a major milestone in the genetics of inflammatory bowel disease, and appears to provide an important link between pathogen recognition and activation of the inflammatory response. Regions of extensive linkage disequilibrium and modest genetic effects are likely to pose significant challenges in the search for novel susceptibility genes.

Keywords:

  • inflammatory bowel disease;
  • Crohn's disease;
  • susceptibility;
  • NOD2;
  • CARD15