Inflammation and inflammatory bowel disease
Part 1. Genetics
1.5. Complex Traits and Diseases
Short Specialist Review
Published Online: 15 NOV 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Mathew, C. G. 2005. Inflammation and inflammatory bowel disease. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.5:62.
- Published Online: 15 NOV 2005
The identification of NOD2 (now called CARD15) as a susceptibility gene for Crohn's disease was a major milestone in the genetics of inflammatory bowel disease, and appears to provide an important link between pathogen recognition and activation of the inflammatory response. Regions of extensive linkage disequilibrium and modest genetic effects are likely to pose significant challenges in the search for novel susceptibility genes.
- inflammatory bowel disease;
- Crohn's disease;