The mitochondrial genome
Part 1. Genetics
1.5. Complex Traits and Diseases
Short Specialist Review
Published Online: 15 NOV 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Wallace, D. C. 2005. The mitochondrial genome. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.5:66.
- Published Online: 15 NOV 2005
The human mitochondrial genome consists of approximately 1500 genes, 37 encoded by the maternally inherited mitochondrial DNA (mtDNA) and the remainder encoded by the nuclear chromosomes. Mutation in the nDNA genes result in Mendelian diseases that affect mitochondrial function or mtDNA replication and stability. Mutations in the mtDNA include ancient adaptive polymorphisms, maternally inherited diseases, and somatic mutations that contribute to age-related diseases, aging, and cancer.
- maternal inheritance;
- degenerative diseases;