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Artificial self-assembling systems for gene therapy

Part 1. Genetics

1.7. Gene Therapy

Short Specialist Review

  1. Pierre Lehn

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g107309

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Lehn, P. 2005. Artificial self-assembling systems for gene therapy. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.7:95.

Author Information

  1. Hôpital Robert Debré, Paris, France

Publication History

  1. Published Online: 15 JAN 2005

Abstract

Over the last decade, a variety of nonviral systems have been developed as an alternative to recombinant viruses for gene delivery. The challenge nowadays is to design improved chemical vectors for more efficient in vivo transfection. Sophisticated multifunctional systems in which each component enables the DNA complex to overcome a critical cellular barrier may be the answer. Such “artificial viruses” may form clinically useful transfection vectors in the future.

Keywords:

  • gene therapy;
  • transfection;
  • nonviral vector;
  • cationic lipid;
  • polymer;
  • lipoplex;
  • polyplex;
  • DNA;
  • plasmid