Artificial self-assembling systems for gene therapy
Part 1. Genetics
1.7. Gene Therapy
Short Specialist Review
Published Online: 15 JAN 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Lehn, P. 2005. Artificial self-assembling systems for gene therapy. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.7:95.
- Published Online: 15 JAN 2005
Over the last decade, a variety of nonviral systems have been developed as an alternative to recombinant viruses for gene delivery. The challenge nowadays is to design improved chemical vectors for more efficient in vivo transfection. Sophisticated multifunctional systems in which each component enables the DNA complex to overcome a critical cellular barrier may be the answer. Such “artificial viruses” may form clinically useful transfection vectors in the future.
- gene therapy;
- nonviral vector;
- cationic lipid;