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Gene transfer to the skin

Part 1. Genetics

1.7. Gene Therapy

Basic Techniques and Approaches

  1. Laurent Gagnoux-Palacios,
  2. Flavia Spirito,
  3. Guerrino Meneguzzi

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g107411

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Gagnoux-Palacios, L., Spirito, F. and Meneguzzi, G. 2005. Gene transfer to the skin. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 1:1.7:103.

Author Information

  1. University of Nice-Sophia Antipolis, Nice, France

Publication History

  1. Published Online: 15 APR 2005

Abstract

The transplantation of autologous artificial epithelia expressing recombinant genes, and direct transfer of DNA to the skin represent potential therapeutic approaches for a local or systemic delivery of active molecules. Successful cutaneous gene therapy trials require development of protocols for efficient gene transfer to epidermal stem cells, and information about the host immune response to the recombinant polypeptides produced by the delivered genes.

Keywords:

  • skin;
  • epidermis;
  • dermis;
  • keratinocyte;
  • vaccination;
  • transplantable epithelia