Eukaryotic genomics

The human genome is perhaps the most famous to be sequenced, but genomes from a diverse array of other eukaryotes are now being compiled. In a few years, genome sequences will be available from all widely studied model organisms and many relatives to facilitate comparative and functional studies. This chapter introduces the strategies that have been used to sequence eukaryotic genomes and some of the issues that affect the choice of strategy.

Keywords: genome assembly; automated DNA sequencing; whole-genome shotgun; hierarchical shotgun; eukaryotic genome projects