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Eukaryotic genomics

Part 2. Genomics

2.1. Genome Sequencing

Introductory Review

  1. Mark D. Adams

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g201101

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Adams, M. D. 2005. Eukaryotic genomics. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.1:1.

Author Information

  1. Case Western Reserve University, Cleveland, OH, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

The human genome is perhaps the most famous to be sequenced, but genomes from a diverse array of other eukaryotes are now being compiled. In a few years, genome sequences will be available from all widely studied model organisms and many relatives to facilitate comparative and functional studies. This chapter introduces the strategies that have been used to sequence eukaryotic genomes and some of the issues that affect the choice of strategy.

Keywords:

  • genome assembly;
  • automated DNA sequencing;
  • whole-genome shotgun;
  • hierarchical shotgun;
  • eukaryotic genome projects