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Genome sequencing of microbial species

Part 2. Genomics

2.1. Genome Sequencing

Introductory Review

  1. Jacques Ravel,
  2. Claire M. Fraser

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g201105

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Ravel, J. and Fraser, C. M. 2005. Genome sequencing of microbial species. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.1:2.

Author Information

  1. The Institute for Genomic Research, Rockville, MD, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

Since the publication of the first complete genome sequence in 1995, of a free-living organism, the bacterium Haemophilus influenzae, more than 220 microbial genomes have been completed and at least another 650 are in progress. Whole-genome shotgun sequencing remains the industry standard and combined with the current state of sequencing technologies, it is expected that the rate at which genomic data is generated is only going to increase. The major challenge is to decipher this wealth of information and link genes to function. In this chapter, the impact of genome sequencing technologies in the field of microbiology is being explored.

Keywords:

  • whole-genome shotgun sequencing;
  • microbial genome;
  • annotation;
  • pathogen;
  • pathogenicity;
  • nonpathogen;
  • archaea;
  • comparative genomics;
  • environmental genomics;
  • genome structure;
  • vaccine;
  • bioinformatics