Genome mapping overview
Part 2. Genomics
Published Online: 15 JUL 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Warren, W. C. and Lovett, M. 2005. Genome mapping overview. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.2:9.
- Published Online: 15 JUL 2005
Genome mapping has had a central and fundamental influence on both genomic sequencing and positional cloning over the past 20 years. The technologies underlying this field fall into three broad categories: (1) true physical maps based upon ordered genomic clones or the cytogenetic map; (2) inferred physical maps based upon a statistical analysis of map order, for example, radiation hybrid (RH) maps; (3) genetic maps that deliver a relative order of polymorphic markers based upon statistical analysis of meiotic recombination crossovers. All three types of reference mapping resources have caveats and limitations. The first is the assumption that the reference map truly reflects the underlying genome. Genomic duplications, inversions, and other complex rearrangements (which may vary between individuals) can complicate the interpretation of these maps. Sex-specific differences can complicate genetic maps. Any type of statistically based map (whether RH or genetic linkage) should be carefully scrutinized for the likely odds of marker order. There are also gaps in many of the available maps and these can also present problems. Here we present a brief overview of the various genome mapping methods.
- genetic mapping;
- physical mapping