Mapping complex disease phenotypes
Part 2. Genomics
Published Online: 15 NOV 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Collier, D. A. 2005. Mapping complex disease phenotypes. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.
- Published Online: 15 NOV 2005
Identifying genetic risk alleles for complex diseases has proved much more difficult than the identification of genetic risk alleles for single-gene disorders. The mapping of complex phenotypes has required the development of new approaches to linkage analysis, the use of nonhuman models of disease, and new approaches to the fine mapping of disease genes, including genome-wide association analysis. In this review, recent developments in these approaches are discussed in detail.
- genetic linkage;
- linkage disequilibrium;
- susceptibility genes;
- quantitative traits;
- meta analysis