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Mapping complex disease phenotypes

Part 2. Genomics

2.2. Mapping

Specialist Review

  1. David A. Collier

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g202201

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Collier, D. A. 2005. Mapping complex disease phenotypes. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.

Author Information

  1. The Institute of Psychiatry, London, UK

Publication History

  1. Published Online: 15 NOV 2005

Abstract

Identifying genetic risk alleles for complex diseases has proved much more difficult than the identification of genetic risk alleles for single-gene disorders. The mapping of complex phenotypes has required the development of new approaches to linkage analysis, the use of nonhuman models of disease, and new approaches to the fine mapping of disease genes, including genome-wide association analysis. In this review, recent developments in these approaches are discussed in detail.

Keywords:

  • genetic linkage;
  • association;
  • linkage disequilibrium;
  • haplotypes;
  • susceptibility genes;
  • quantitative traits;
  • meta analysis