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Fingerprint mapping

Part 2. Genomics

2.2. Mapping

Short Specialist Review

  1. Jacqueline E. Schein,
  2. Martin I. Krzywinski

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g202310

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Schein, J. E. and Krzywinski, M. I. 2005. Fingerprint mapping. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.

Author Information

  1. British Columbia Cancer Agency, Genome Sciences Centre, Vancouver, BC, Canada

Publication History

  1. Published Online: 15 NOV 2005

Abstract

Restriction fingerprint maps have played a significant role in genomics research over the past 35 years. Representing the size and order of restriction endonuclease fragments along the genome, these maps provided a physical framework on which to locate known features and functions in genomes of early scientific interest. Over the last 20 years, large-insert, clone-based fingerprint maps have been critical components in genome mapping and sequencing projects, including those for Caenorhabditis elegans, Saccharomyces cervisiae, Mus musculus, and Homo sapiens. In this review, we provide a summary of the evolution of fingerprint mapping, and an overview of the current methodologies used and technical considerations for the generation of ordered-clone fingerprint maps.

Keywords:

  • fingerprint;
  • restriction enzyme fingerprint;
  • physical map;
  • bacterial artificial chromosome;
  • electrophoresis