Part 2. Genomics
Short Specialist Review
Published Online: 15 NOV 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Schein, J. E. and Krzywinski, M. I. 2005. Fingerprint mapping. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.
- Published Online: 15 NOV 2005
Restriction fingerprint maps have played a significant role in genomics research over the past 35 years. Representing the size and order of restriction endonuclease fragments along the genome, these maps provided a physical framework on which to locate known features and functions in genomes of early scientific interest. Over the last 20 years, large-insert, clone-based fingerprint maps have been critical components in genome mapping and sequencing projects, including those for Caenorhabditis elegans, Saccharomyces cervisiae, Mus musculus, and Homo sapiens. In this review, we provide a summary of the evolution of fingerprint mapping, and an overview of the current methodologies used and technical considerations for the generation of ordered-clone fingerprint maps.
- restriction enzyme fingerprint;
- physical map;
- bacterial artificial chromosome;