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The Happy mapping approach

Part 2. Genomics

2.2. Mapping

Short Specialist Review

  1. Francis Galibert

Published Online: 15 JUL 2005

DOI: 10.1002/047001153X.g202314

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Galibert, F. 2005. The Happy mapping approach. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.2:22.

Author Information

  1. Génétique et Développement, Rennes, France

Publication History

  1. Published Online: 15 JUL 2005

Abstract

“Happy mapping” is an in vitro genome mapping method for type 1 and 2 markers that offers several advantages over the RH method. However, it is highly dependent on a whole-genome amplification step that till now has been difficult to realize given the very small amount of starting DNA. In this article, advantages and possible future developments are discussed in light of the difficulties inherent in the method.

Keywords:

  • Happy mapping;
  • RH mapping;
  • whole-genome amplification;
  • degenerated PCR;
  • microarrays