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Transcriptional promoters

Part 2. Genomics

2.3. The Human Genome

Short Specialist Review

  1. Wyeth W. Wasserman

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g203309

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Wasserman, W. W. 2005. Transcriptional promoters. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.

Author Information

  1. University of British Columbia, Vancouver, BC, Canada

Publication History

  1. Published Online: 15 NOV 2005

Abstract

Transcription serves as a primary mechanism for regulating the activity of most genes in the human genome. Multiple regulatory mechanisms act together to influence the rate of initiation of transcription from specific regions in genes termed promoters. Genes may contain multiple promoters, and promoters may contain multiple sites of transcript initiation. A brief biochemical background is presented, followed by an overview of the properties of promoters that facilitate laboratory detection and bioinformatics prediction.

Keywords:

  • transcription;
  • promoter;
  • chromatin immunoprecipitation (ChIP);
  • gene expression;
  • CpG islands;
  • methylation;
  • transcription factors;
  • polymerase