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Comparisons with primate genomes

Part 2. Genomics

2.3. The Human Genome

Short Specialist Review

  1. Mariano Rocchi,
  2. Nicoletta Archidiacono

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g203310

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Rocchi, M. and Archidiacono, N. 2005. Comparisons with primate genomes. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.3:32.

Author Information

  1. University of Bari, Bari, Italy

Publication History

  1. Published Online: 15 JAN 2005

Abstract

Molecular cytogenetic tools, whole-chromosome paints in particular, have been extensively used to disclose changes that have shaped the karyotype organization of primates. In addition, detailed marker order arrangement defined by using appropriate BAC and PAC probes have revealed the relatively frequent occurrence of an unprecedented phenomenon: the centromere repositioning during evolution. Remains of evolutionary inactivated centromeres appears to play a key role in the emergence of neocentromeres in human clinical cases.

Keywords:

  • karyotype evolution;
  • genome comparison;
  • centromere repositioning