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Human microRNAs

Part 2. Genomics

2.3. The Human Genome

Short Specialist Review

  1. Sam Griffiths-Jones

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g203316

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Griffiths-Jones, S. 2005. Human microRNAs. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.3:34.

Author Information

  1. The Wellcome Trust Sanger Institute, Cambridge, UK

Publication History

  1. Published Online: 15 APR 2005

Abstract

MicroRNAs (miRNAs) are a diverse class of 20–22 nucleotide small RNAs that regulate translation of a wide range of genes by complementary binding to untranslated regions of mRNA targets. Over 1300 miRNA sequences have been identified from animals and plants, with over 200 genes in the human genome. miRNAs appear to be expressed from a variety of genomic contexts including from autonomous promoters, as polycistronic transcripts, and processed from introns of protein-coding genes.

Keywords:

  • microRNA;
  • noncoding RNA;
  • gene structure;
  • translation repression;
  • polycistronic