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The rat as a model physiological system

Part 2. Genomics

2.4. Model Organisms: Functional and Comparative Genomics

Specialist Review

  1. Dominique Gauguier

Published Online: 15 JUL 2005

DOI: 10.1002/047001153X.g204205

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Gauguier, D. 2005. The rat as a model physiological system. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.4:39.

Author Information

  1. University of Oxford, Oxford, UK

Publication History

  1. Published Online: 15 JUL 2005

Abstract

The laboratory rat is a major experimental animal in all fields of biomedical research. It provides a broad range of models for accurately characterizing the effects of naturally occurring gene variants on the regulation of complex phenotypes underlying the pathogenesis of common and prevalent human genetic disorders. The completion of the rat genome sequence and progress in comparative genomics provide key resources that facilitate the characterization of disease genes at quantitative trait loci (QTLs). Genetic, physiological, and functional genomics investigations in existing inbred rat strains and emerging congenic and consomic panels are now contributing, in combination with studies in mouse models, to the functional annotation of mammalian genomes, and the identification of candidate genes for human multifactorial diseases.

Keywords:

  • rat;
  • rodent;
  • quantitative trait locus;
  • QTL;
  • complex traits;
  • physiology;
  • genetics;
  • congenics;
  • comparative genomics