Systematic mutagenesis of nonmammalian model species
Part 2. Genomics
2.4. Model Organisms: Functional and Comparative Genomics
Published Online: 15 NOV 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
van den Heuvel, M. and Sattelle, D. 2005. Systematic mutagenesis of nonmammalian model species. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.4:42.
- Published Online: 15 NOV 2005
The recent accumulation of whole-genome sequence information has led to the notion that the degree of evolutionary conservation between diverse organisms is very high. The number of genes going from a fly to human is only about twofold, and many of these “new” genes are duplicates of genes already existing, not novel genes. This in fact means that organisms that have been thoroughly studied using genetics offer a direct entrance into the function of highly conserved genes. Two of such organisms stand out because of the sophistication and thoroughness of the studies, the worm, Caenorhabditis elegans, and the fly, Drosophila melanogaster. This review attempts to give these two organisms a place in the current drive in gene function analysis.
- gene function;
- Drosophila melanogaster;
- Caenorhabditis elegans;
- historical perspective;
- mutagenesis screens