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Functional genomics in Saccharomyces cerevisiae

Part 2. Genomics

2.4. Model Organisms: Functional and Comparative Genomics

Short Specialist Review

  1. Kara Dolinski,
  2. Olga Troyanskaya

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g204307

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Dolinski, K. and Troyanskaya, O. 2005. Functional genomics in Saccharomyces cerevisiae. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.4:43.

Author Information

  1. Princeton University, Princeton, NJ, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

The availability of the Saccharomyces cerevisiae genome has fueled an explosion of high-throughput methods aimed at the functional characterization of all proteins in yeast. These diverse methods include expression and protein microarray experiments, protein–protein and protein–DNA interaction studies, proteomics data, and phenotype analyses. Integrated bioinformatics analysis is necessary to utilize the full potential of these data. Such analysis can be facilitated by public distribution of these data sets in standardized form and by development of accurate and efficient analysis algorithms. In this chapter, we outline available data sources and their distribution, data sharing standards, and data integration methods.

Keywords:

  • Saccharomyces cerevisiae;
  • functional genomics;
  • data standards;
  • data integration;
  • Bayesian network