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Comparative sequencing of vertebrate genomes

Part 2. Genomics

2.4. Model Organisms: Functional and Comparative Genomics

Short Specialist Review

  1. Matthew E. Portnoy,
  2. Eric D. Green

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g204314

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Portnoy, M. E. and Green, E. D. 2005. Comparative sequencing of vertebrate genomes. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.4:48.

Author Information

  1. National Human Genome Research Institute, Bethesda, MD, USA

Publication History

  1. Published Online: 15 JAN 2005

Abstract

The areas of large-scale DNA sequencing and sequence analysis are undergoing a rapid metamorphosis, as priorities shift from generating genome sequences for a select group of reference species to interpreting the information encoded therein. Comparison of the human genome sequence with that of other vertebrates has emerged as a critical component of this interpretative process. Newly developed experimental and computational methods are providing more powerful approaches for comparative sequence analyses, and in turn, these are being used for systematically unraveling the complexities of vertebrate genomes.

Keywords:

  • genome sequencing;
  • comparative genomics;
  • vertebrate;
  • genome analysis;
  • genome annotation