Genomics of the Mycobacterium tuberculosis complex and Mycobacterium leprae
Part 2. Genomics
2.5. Bacteria and Other Pathogens
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Gordon, S. V. and Brosch, R. 2005. Genomics of the Mycobacterium tuberculosis complex and Mycobacterium leprae. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.5:52.
- Published Online: 15 APR 2005
Diseases caused by mycobacteria continue to exact a terrible burden across the globe, with an urgent need for new treatments and control strategies. Elucidation of the genome sequences of these pathogens therefore offers a cost-effective approach to catalyze research and accelerates our understanding of them. The genome sequence of the hallmark strain, Mycobacterium tuberculosis H37Rv, has been available since 1997 and this serves as the lynchpin for comparative genomics across the complex. Our review will use comparative genomics to explore the wealth of sequence data available for the pathogenic mycobacteria and highlight similarities and parallels that impact upon important biological characteristics. Such analyses are providing novel insights into how pathogenic mycobacteria exploit the in vivo niche, and in so doing expose targets for drug development and diagnostic reagents.
- comparative genomics;