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Genomics of the Mycobacterium tuberculosis complex and Mycobacterium leprae

Part 2. Genomics

2.5. Bacteria and Other Pathogens

Specialist Review

  1. Stephen V. Gordon1,
  2. Roland Brosch2

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g205204

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Gordon, S. V. and Brosch, R. 2005. Genomics of the Mycobacterium tuberculosis complex and Mycobacterium leprae. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.5:52.

Author Information

  1. 1

    Veterinary Laboratories Agency, New Haw, UK

  2. 2

    Institut Pasteur, Paris, France

Publication History

  1. Published Online: 15 APR 2005

Abstract

Diseases caused by mycobacteria continue to exact a terrible burden across the globe, with an urgent need for new treatments and control strategies. Elucidation of the genome sequences of these pathogens therefore offers a cost-effective approach to catalyze research and accelerates our understanding of them. The genome sequence of the hallmark strain, Mycobacterium tuberculosis H37Rv, has been available since 1997 and this serves as the lynchpin for comparative genomics across the complex. Our review will use comparative genomics to explore the wealth of sequence data available for the pathogenic mycobacteria and highlight similarities and parallels that impact upon important biological characteristics. Such analyses are providing novel insights into how pathogenic mycobacteria exploit the in vivo niche, and in so doing expose targets for drug development and diagnostic reagents.

Keywords:

  • Mycobacterium;
  • tuberculosis;
  • leprosy;
  • comparative genomics;
  • BCG