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The Mycoplasmas – a congruent path toward minimal life functions

Part 2. Genomics

2.5. Bacteria and Other Pathogens

Specialist Review

  1. Leka Papazisi,
  2. Scott N. Peterson

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g205206

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Papazisi, L. and Peterson, S. N. 2005. The Mycoplasmas – a congruent path toward minimal life functions. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.5:53.

Author Information

  1. The Institute for Genomic Research, Rockville, MD, USA

Publication History

  1. Published Online: 15 NOV 2005

Abstract

The Mycoplasmas are a group of pathogenic bacteria with highly reduced genomes. The genomic era has allowed comparison of Mycoplasma genomes to one another and to less-related genomes. Genomic analysis of this bacterial group reveals several interesting aspects of minimal genome characteristics that have allowed us to devise a specific model to account for aspects of reductive evolution in the Mycoplasmas.

Keywords:

  • minimal genome;
  • mycoplasma;
  • reductive evolution;
  • genome organization;
  • regulation of gene expression;
  • protein folding;
  • gene essentiality;
  • substrate specificity;
  • genomic economy;
  • enzyme evolution