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Genomics of Rickettsia

Part 2. Genomics

2.5. Bacteria and Other Pathogens

Short Specialist Review

  1. Hiroyuki Ogata1,
  2. Didier Raoult2

Published Online: 15 APR 2006

DOI: 10.1002/047001153X.g205302

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Ogata, H. and Raoult, D. 2006. Genomics of Rickettsia. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.5.

Author Information

  1. 1

    Structural & Genomic Information Laboratory, UPR 2589, IBSM, CNRS, Parc Scientifique de Luminy, 13288 Marseille Cedex 9, France

  2. 2

    Unité des Rickettsies, UMR 6020, IFR 48, CNRS, Faculté de Médecine, 13385 Marseille Cedex 5, France

Publication History

  1. Published Online: 15 APR 2006

Abstract

Rickettsia are obligate intracellular bacteria associated with arthropods. Many Rickettsia species are the agents of human diseases. During the last years, genome sequence analysis has substantially advanced our understanding of the parasitic lifestyle and the virulence mechanisms of the microorganisms. Comparative genome analysis provided insights into the evolutionary mechanisms through which Rickettsia have adapted to their intracellular life.

Keywords:

  • intracellular bacteria;
  • genome reduction;
  • plasmids;
  • conjugation;
  • evolution