Methods for detecting horizontal transfer of genes
Part 2. Genomics
2.5. Bacteria and Other Pathogens
Short Specialist Review
Published Online: 15 OCT 2004
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Lawrence, J. G. 2004. Methods for detecting horizontal transfer of genes. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.5:66.
- Published Online: 15 OCT 2004
Horizontal gene transfers are events that have no eyewitnesses; therefore, inferences regarding the nature and even existence of transfer events rely solely upon circumstantial evidence. Two general approaches have been taken to identify genes having participated in gene exchange: either examining the evolutionary history of a gene within its phylogenetic context and equating an incongruity with a transfer or examining the sequence composition of a gene within its genomic context and attributing incongruity with differential history. In both cases, discordance can arise from sources aside from gene transfer, and the degree of the discordance can provide some measure of confidence that a transfer has occurred.
- gene transfer;
- GC content;
- dinucleotide frequencies;
- Markov models;