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Genome-wide analysis of group A Streptococcus

Part 2. Genomics

2.5. Bacteria and Other Pathogens

Short Specialist Review

  1. Nicole M. Green1,2,
  2. James M. Musser1

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g205308

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Green, N. M. and Musser, J. M. 2005. Genome-wide analysis of group A Streptococcus. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.5:57.

Author Information

  1. 1

    Baylor College of Medicine, Houston, TX, USA

  2. 2

    University of California Davis, Davis, CA, USA

Publication History

  1. Published Online: 15 APR 2005

Abstract

The human pathogenic bacterium group A Streptococcus (GAS) is a major cause of morbidity and mortality worldwide. The genomes of seven GAS strains commonly causing pharyngitis and invasive disease have been sequenced recently. These genome sequences have yielded extensive new information important for GAS pathogenesis research, and have provided new insight into the extent of strain variation within and between serotypes. Importantly, these studies have revealed that bacteriophages are the primary source of variation in gene content between strains. Genome-wide studies also have provided important new data bearing on the molecular mechanisms underlying changes in GAS epidemic behavior. Expression microarray analyses have identified genes and gene networks used by GAS to respond and survive in various environments, including exposure to human polymorphonuclear leukocytes and whole blood. Taken together, genome-wide study of GAS is an area of intensive research that has greatly enhanced our understanding of this pathogen.

Keywords:

  • genome;
  • group A Streptococcus;
  • evolution;
  • prophage;
  • pathogenesis;
  • microarray