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Chlamydiae

Part 2. Genomics

2.5. Bacteria and Other Pathogens

Short Specialist Review

  1. Timothy D. Read

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g205312

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Read, T. D. 2005. Chlamydiae. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.5:59.

Author Information

  1. Biological Defense Research Directorate, Naval Medical Research Center, Rockville, MD, USA

Publication History

  1. Published Online: 15 JAN 2005

Abstract

The chlamydiae are a group of obligate intracellular pathogens with a unique biphasic life cycle. The six genomes sequenced are approximately 1.05–1.2 Mb and show no signs of pathogenicity islands or other recent horizontal transfer events. There are about 750 genes conserved across all genomes, encoding core functions. Potential virulence determinants include type III secretion systems, toxins, variable surface proteins, and tryptophan biosynthesis proteins.

Keywords:

  • intracellular pathogen;
  • atherosclerosis;
  • trachoma bacteriophage;
  • type III secretion;
  • tryptophan;
  • toxin