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Spirochete genomes

Part 2. Genomics

2.5. Bacteria and Other Pathogens

Short Specialist Review

  1. George Weinstock

Published Online: 15 JUL 2005

DOI: 10.1002/047001153X.g205317

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Weinstock, G. 2005. Spirochete genomes. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.5:60.

Author Information

  1. Baylor College of Medicine, Houston, TX, USA

Publication History

  1. Published Online: 15 JUL 2005

Abstract

Spirochetes are a group of bacteria with a common threadlike morphology. Nevertheless, these organisms show great genomic diversity, ranging in size from 1 to over 4 Mb and in chromosome structure from the simple bacterial circular chromosome to complex collections of linear and circular chromosomes. The gene content of pathogenic spirochetes often shows few of the virulence factors found in the more extensively studied Proteobacteria or gram-positive bacteria. This may reflect the significant evolutionary distance from spirochetes to these other microbes as well as different strategies of infection.

Keywords:

  • syphilis;
  • Lyme disease;
  • leptospirosis;
  • periodontitis;
  • gingivitis