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Comparative genomics of the ɛ-proteobacterial human pathogens Helicobacter pylori and Campylobacter jejuni

Part 2. Genomics

2.5. Bacteria and Other Pathogens

Short Specialist Review

  1. Nick Dorrell,
  2. Brendan Wren

Published Online: 15 JAN 2005

DOI: 10.1002/047001153X.g205318

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Dorrell, N. and Brendan, W. 2005. Comparative genomics of the ɛ-proteobacterial human pathogens Helicobacter pylori and Campylobacter jejuni. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.5:61.

Author Information

  1. London School of Hygiene & Tropical Medicine, London, UK

Publication History

  1. Published Online: 15 JAN 2005

Abstract

Helicobacter pylori and Campylobacter jejuni are among the most common bacterial pathogens encountered by humans, but despite the prevalence and importance of the diseases caused by these organisms, they have only been recognized as human pathogens within the last 25 years. However, they are now among the most comprehensively studied organisms, due in no small part to the availability of complete genome sequences for both bacteria. Subsequent genomic studies have started to explain the genetic, ecological, and pathogenic similarities and differences between these two major human pathogens. Understanding the dynamic and complex interplay between these pathogens and the host will place the emphasis on converting this knowledge into appropriate intervention strategies to reduce the burden on human health.

Keywords:

  • Helicobacter pylori;
  • Campylobacter jejuni;
  • comparative genomics;
  • genome sequence;
  • capsule;
  • glycosylation;
  • urease;
  • cag pathogenicity island;
  • phase variation;
  • microarrays