History of genetic mapping
Part 2. Genomics
Published Online: 15 OCT 2004
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Morton, N. E. 2004. History of genetic mapping. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.6:67.
- Published Online: 15 OCT 2004
Unlike physical maps, genetic maps are not directly derived from the DNA sequence. There are two types of genetic maps based on linkage and allelic association (linkage disequilibrium), respectively. Linkage maps are a century old and their use is stable, performing well in assigning a gene of unknown structure and function to a broad candidate region. Association maps were impossible until a trustworthy physical map became available and the block structure of linkage disequilibrium became known. Their use is in rapid evolution because (like functional tests) they are more efficient than linkage in identifying a causal locus within a candidate region. The questions raised by association mapping, although too new to be found in textbooks, are being pursued by many investigators.
- linkage disequilibrium