SNPs and human history
Part 2. Genomics
Published Online: 15 JUL 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Wall, J. D. 2005. SNPs and human history. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.6:71.
- Published Online: 15 JUL 2005
Evolutionary geneticists have shown great interest in using patterns of single-nucleotide polymorphism (SNP) variation to make inferences about models of human evolution. Although there is a large amount of variability in the patterns across regions, a couple of trends have emerged: overall levels of variability are low, indicative of a small historical effective population size, and there are systematic differences in the patterns of SNP variation both across different regions of the genome and across human populations. The connections between these broad patterns and models of human evolution are unclear, in part because of the difficulty in quantifying the verbal models of physical anthropology. This will change soon with the development of new analytical methods and the gathering of more human SNP data.
- human evolution;
- natural selection;
- population bottlenecks;
- population structure;