Evolutionary modeling in haplotype analysis
Part 2. Genomics
Short Specialist Review
Published Online: 15 JUL 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Donnelly, P. 2005. Evolutionary modeling in haplotype analysis. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.6:72.
- Published Online: 15 JUL 2005
Data that captures genetic variation at closely spaced markers in samples from a population is the result of various evolutionary and chance forces. Interpretation of such data is often aided by an understanding of these evolutionary processes, and statistical methods that explicitly model aspects of the evolutionary history, including coalescent-based approaches, are often more powerful than available alternatives, even for applications such as disease gene mapping when the evolutionary processes are not of primary interest.
- linkage disequilibrium;
- disease genetics;
- phase inference