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Evolutionary modeling in haplotype analysis

Part 2. Genomics

2.6. SNPs/Haplotypes

Short Specialist Review

  1. Peter Donnelly

Published Online: 15 JUL 2005

DOI: 10.1002/047001153X.g206305

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Donnelly, P. 2005. Evolutionary modeling in haplotype analysis. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 2:2.6:72.

Author Information

  1. University of Oxford, Oxford, UK

Publication History

  1. Published Online: 15 JUL 2005

Abstract

Data that captures genetic variation at closely spaced markers in samples from a population is the result of various evolutionary and chance forces. Interpretation of such data is often aided by an understanding of these evolutionary processes, and statistical methods that explicitly model aspects of the evolutionary history, including coalescent-based approaches, are often more powerful than available alternatives, even for applications such as disease gene mapping when the evolutionary processes are not of primary interest.

Keywords:

  • coalescent;
  • linkage disequilibrium;
  • disease genetics;
  • phase inference