Disease gene candidacy and ESTs
Part 2. Genomics
2.7. ESTs: Cancer Genes and the Anatomy Project
Short Specialist Review
Published Online: 15 APR 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
McCarthy, M. I. 2005. Disease gene candidacy and ESTs. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.
- Published Online: 15 APR 2005
The effort to identify and characterize the genetic variants that underlie susceptibility to common multifactorial traits represents one of the main challenges in biomedical research today. Key to this research is the capacity to assess the biological candidacy of potential susceptibility genes by matching their characteristics to known features of the disease. Tissue expression patterns provide one of the most obvious and useful parameters in this respect. There is a growing body of available data on the expression state of human genes, including information inherent in the tissue origins of the expressed sequence tags (ESTs) that can be associated with a chosen transcript. This short review discusses the value of transcript sequence data in the mapping of human disease genes.
- expressed sequence tags;
- complex traits;
- biological candidacy;
- expression profiling